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ASC-H
The University of Texas at San Antonio
and HSIL. Secondly
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ROLE OF INTRACELLULAR MEMBRANE SIGNALOSOMES IN B CELL NF-KAPPAB ACTIVATION

Role of intracellular membrane signalosomes in B cell NF-kB activationThis proposal focuses on a novel mechanism that underlies NF-kB activation in peripheral B cell differentiationand, when dysregulated in autoreactive B cells, promotes pathogenic autoantibody responses in autoimmunediseases, such as lupus. As we contend, this mechanism is underpinned by the formation of intracellularmembrane signalosomes (IM signalosomes), e.g., as mediated by the interaction of signal adaptor TRAF6, anE3 ubiquitin ligase, with Rab7, an endosome-tethered small GTPase, in B cells upon CD40 engagement.

UT Health San Antonio
Xu, Zhenming
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