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In contrast. nonconserved positions are sel??dom mu??tated in the lab. even though they often comprise >50% of the positions in a sequence align??ment. Moreover. nonconserved posi??tions can make impor??tant contributions to function: Pro??tein paralogs evolve functional variation via chan??ges at noncon??served positions; changes at noncon??served positions also cause disease.refPYK We hypo??thesized that. for a subset of nonconserved positions. the assumptions above give rise to false mutation predictions.

The University of Texas at San Antonio

The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.

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