Facilitated By

San Antonio Medical Foundation

This hy??pothesis is supported by our experi??ments with LacI/GalR ho??mologs.4Using these proteins. we identified a class of important. non??con??ser??v??ed ami??no acid po??si??tions that does not fol??low any of the rules in Box 1. Our ongoing experiments show that predictions for substi??tu-tion out??comes have nearly zero power at these positions. We named this group ???rheostat positions???. after their most prominent cha??racteristic: When multiple amino acids were substituted at one rheostat position. functions of the mutant proteins could be rank-order??ed to show a pro??gressive effect (Fig. 1A. page 3).

The University of Texas at San Antonio

The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.

Research Start Date
Collaborative Project