Hypertension affects millions of people in the United States and worldwide. Improved understanding of themolecular and cellular origins of hypertension will improve the efficacy of treatment and diagnosis. TheEpithelial Na+ Channel, ENaC, is the final arbiter of Na+ excretion in the kidneys. As such, discretionary controlof ENaC fine-tunes renal excretion. Appropriate renal excretion is a key factor in the normal regulation ofarterial blood pressure. Consequently, dysfunction of ENaC and its upstream modulators cause dysregulationof blood pressure due to abnormal excretion.