BioBridge Global is a San Antonio, Texas-based nonprofit corporation that offers diverse services through its subsidiaries – the South Texas Blood & Tissue Center, QualTex Laboratories, GenCure and the Blood & Tissue Center Foundation.
Principal Investigator(s)
Rogelio Zamilpa
Develop a process to isolate and characterize human umbilical cord blood plasma
EO2 Concepts (EO2), is an advanced wound care technology company.
Principal Investigator(s)
Joseph Mills, MD, FACS
Bijan Najafi, PhD
Funded by
EO2
Collaborating Institutions
Baylor College of Medicine, Houston, TX
Test the efficacy of the novel Oxyspur dressing in concert with TransCu Oxygen delivery system for use in caring for patients with lower extremity diabetic foot ulcers. We will assess the benefits of this novel therapy on would healing, vascular parameters, skin perfusion and quality of life. This study is being conducted at the Baylor College of Medicine, Houston, TX.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Clark, Curtis
Funded by
NIH
Factors in the tumor microenvironment promote immunosuppression that permits tumor escape from immune destruction. Our data show that tumor PD-L1 (CD274, B7-H1) is a major regulator of tumor inflammatory lymphocyte (TIL) infiltrate. PD-L1 is widely expressed in many tumors and is the target of two successful new cancer immunotherapy approaches, but is a poor predictor of treatment efficacy.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Penalva, Luiz Otavio
Funded by
NIH
Glioblastoma multiforme (GBM) is a highly malignant brain tumor type with 14 months average patient survival, high incidence of recurrence and no effective line of treatment. Genomic analyses became an essential resource to understand the molecular alterations that cause cancer. In the case of GBM, analysis of hundreds of samples produced an extensive transcriptomic map, identified prevalent mutations and defined important tumor drivers. Unfortunately, clinical trials based on these results have not yet delivered positiv outcomes.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Sharp, Zelton Dave
Funded by
NIH
Delaying the onset of cancer may be a viable cancer prevention strategy, but until now research efforts on this aspect are indeed limited. To this end,we are relatively advanced because our published results establish that organ specific delivery of eRapa (a novel formulation of rapamycin) can delay the development of intestinal tumors in a mouse model of familial adenomatous polyposis (FAP) and thus extended life as well as health span.
59th Medical Wing at the Wilford Hall Ambulatory Surgical Center (WHASC)
The 59th Medical Wing at the Wilford Hall Ambulatory Surgical Center (WHASC) provides support for research conducted by investigators and their collaborators addressing the unique scientific needs of the Air Force, the Department of Defense and the Nation.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Sun, Luzhe
Funded by
NIH
Our long-term goal is to determine how the aging-related breast cancer can be specifically prevented. This is an unanswered question largely because the cellular and molecular mechanisms underlying the aging-related increase in breast cancer incidence are poorly understood. We recently found that the percentage of mammary stem cells (MaSCs) in mouse mammary gland increases steadily with age.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Ayala, Iriscilla Imabary
Funded by
NIH
Type 2 diabetes (T2D) affects approximately 8.3% of the United States population. Family history is one of the major risk factors for T2D noncoding genetic variation in the transcription factor 7-like 2 (TCF7L2) gene is significantly associated with T2D in multiple ethnic populations, yet the biological mechanism(s) that lead to increased risk are still unclear. Evidence for involvement of the central nervous system (CNS) in regulating fasting and postprandial glucose levels continues to grow, and TCF7L2 localization in the hypothalamus suggests a potential role in glucose regulation.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Harris, Stephen Eubank
Funded by
NIH
Fundamental knowledge of the periodontium is required to develop new approaches to understand and treat this major health problem. This project is directed at understanding the role and mechanism of the Bmp2 gene and Sost gene in periodontium function. Our recent published results indicate that the mouse Bmp2 gene in stem-progenitor cells in the periodontium is required for the development of the periodontium and formation of tooth root.