Southwest Research Institute (SwRI), headquartered in San Antonio, Texas, is one of the oldest and largest independent, nonprofit, applied research and development (R&D) organizations in the United States.
Principal Investigator(s)
Dr. Mark Libardoni
Funded by
SwRI
Traumatic brain injury (TBI) is the most common cause of cognitive and behavioral deficits in the U.S and worldwide. Most TBIs are classified as mild-TBI and concussion (C) that are associated with minor symptoms and microscopic damage with no observable pathology on imaging scans, and thus are challenging to be diagnosed. Equally important are asymptomatic sub-concussive (SC) head exposures that when left undiagnosed put the subjects at higher risk of repeated exposures, resulting in cognitive declines and initiation of chronic neurodegenerative disease.
59th Medical Wing at the Wilford Hall Ambulatory Surgical Center (WHASC)
The 59th Medical Wing at the Wilford Hall Ambulatory Surgical Center (WHASC) provides support for research conducted by investigators and their collaborators addressing the unique scientific needs of the Air Force, the Department of Defense and the Nation.
The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.
Principal Investigator(s)
Guda, Teja
Seshu, Janakiram
Flores, Mario
Funded by
UTSA VPR Office
In light of the currently extant Covid pandemic. the impact of understanding upper airway health and being prepared for the rapid development of novel therapeutics has been reinforced. While preclinical animal models have long been the gold standard for the testing and development of novel therapeutics. they are expensive and time consuming. The availability of validated. reproducible and scalable in vitro diagnostics that reproduce relevant physiology and function as test-benches for the rapid testing and development of personalized medicine therapeutics is thus invaluable.
The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.
Principal Investigator(s)
Ye, JingYong
Funded by
UTSA VPR Office
In the U.S. alone, 2.8 million people sustain a traumatic brain injury (TBI) each year and seek medical care.1,2 However, there are no FDA approved therapies for effective treatment of TBI (or concussion) patients. Current medications are limited to only reducing secondary damage to the brain following TBI, such as using diuretics to reduce the pressure inside the brain by increasing urine output.
As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Daadi, Marcel M
Collaborating Institutions
University of California Irvine
Major Goal: The goal of this grant application is to produce clinical grade human neural stem cells from embryonic stem cells and to demonstrate their long-term safety and efficacy in a rodent and a nonhuman primate model (marmoset) of acute focal traumatic brain injury (TBI).