As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Ross, Corinna
Funded by
National Institutes of Health
As the human population shifts to a higher proportion of aged and geriatric individuals, it is critical that we develop appropriate animal models in which to test interventional methods to maintain human health and to systemically treat age-related disease. Marmosets offer a unique model in which to evaluate the translational gap between cellular aging and clinical application.
As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Ross, Corinna
We have previously found that geriatric marmosets have a significantly reduced microbial diversity, and we have also found in pilot testing that oral fecal transplant can be safely used to alter a young animal?s microbial community. We hypothesize that loss of microbial diversity is significantly associated with the aging process, and that oral FMT may be a potential therapeutic for healthspan maintenance. Specific Aim 1: Determine if changes in the gut microbiome with aging are associated with significant changes in measures of healthspan and lifespan.
As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Kaushal, Deepak
Funded by
National Institutes of Health
This major goal of this funding is to outfit the Pathology Unit of SNPRC with a new chemistry analyzer, a new slide stainer and coverslipper, as well as seeks to purchase a state of the art whole slide scanner, which will provide a significant upgrade to research capabilities supported by Texas Biomed.
The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.
Principal Investigator(s)
Lamb, Audrey
Funded by
Natl Science Fdn
This research project will be undertaken to define the structure-function relationships of the enzymes of riboflavin biosynthesis.Riboflavin biosynthesis includes five enzymatic activities that are unparalleled in nature. This pathway has been studied in sufficient detail to establish the chemical transformations performed by each enzyme and the salient characteristics of the enzymes. The focus of this proposal is the mechanisms of the unusual deformylation reactions of RibA and RibB and the unconventional multi-activity of RibD will be defined.
As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Turner, Joanne
Core instrumentation for the Biology Core to expand the flow cytometry capabilities.
As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Schlesinger, Larry S
Funded by
Kronkosky Charitable Foundation
The purpose of this grant is for the purchase of a Confocal Microscope for Core Research Support project.
As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Daadi, Marcel M
Funded by
National Institutes of Health
The overarching goal of this proposal is to establish the baboon as a relevant model of age-related cognitive impairment by validating behavioral, cognitive, and neuroanatomical features affected in aged baboons and identifying the appropriate miRNA biomarkers that may be causal of the age-related structural and functional changes.
As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Schlesinger, Larry S
Funded by
National Institutes of Health
The major goal is to increase primate holding capacity for the P51 base grant.
As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Leopold Wager, Chrissy M
M. tuberculosis, which causes the worldwide global health problem tuberculosis (TB), is transmitted human to human via the airborne route into lung alveoli and ultimately exploits and grows in host macrophages. We seek to understand the cell signaling pathways initiated by infection of human macrophages with M. tuberculosis that lead to disease. Increased understanding of how macrophages are susceptible to M. tuberculosis is expected to aid in the development of host-directed therapies for TB.
The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.
Principal Investigator(s)
Perry, George
Plascencia Villa, German
Funded by
Univ of TX HSC at Houston 744
Alzheimer's disease (AD) is increasing in number as the U.S. and global population gets older. Despite enormous effort and expense. treatment remains at best modestly effective and no new drugs have been approved since 2003 [1.2]. The increasing interest in drug discovery through repositioning old drugs for new therapeutic applications throw light in the treatment for neurodegenerative diseases including AD [3].