As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Mohan, Mahesh
The proposed studies is aimed at understanding the molecular mechanisms underlying oral mucosal dysfunction and developing novel immune
The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.
Principal Investigator(s)
McHardy, Stanton
Funded by
Univ of TX HSC at San Antonio 745
The systemic inflammatory response in sepsis has devastating consequences resulting in high morbidity and mortality. Over the past decade. mortality from sepsis alone has remained greater than 25%. despite effective antimicrobial therapy. In particular. the survival rate of the Hispanic population with other complications and combat casualties are often poorer. This highlights lack of understanding of the pathways operative in sepsis and the necessity for improved therapies. One of the major changes that occur during Multi-organ-failure (MOF) in severe sepsis is mitochondrial dysfunction.