As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Ebrahimi, Diako
Collaborating Institutions
University of Texas Health Science Center San Antonio
We aim to fully characterize mutational signatures of SARS-CoV-19 focusing on the furin cleavage site, determine the role of the GC-rich sequence and CpG sites within the furin cleavage site and develop neutralizing Abs to target the furin cleavage site.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Musi, Nicolas
For the past three decades, the University of Texas Health Science Center at San Antonio (UTHSCSA) hashosted a premier Training Program in the biology of aging that has resulted in the development of a newgeneration of leaders in this field. This application seeks to continue this T32 Training Program and we requestfunds to support four predoctoral and four postdoctoral trainees.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Ran, Qitao
Funded by
NIH-NATIONAL INSTITUTE ON AGING
Alzheimer's disease (AD) is the most common neurodegenerative disease affecting millions of Americans.Neurons have a large amount of polyunsaturated fatty acids in membrane phospholipids that are vulnerable toattack by reactive oxygen species to result in lipid peroxidation. Lipid peroxidation is increased in AD brains andis believed to play a key role in driving neurodegeneration of AD. However, supplementation of lipid solubleantioxidants yields only mixed results in clinical trials. So the importance of lipid peroxidation in AD remainsunproven.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Frost, Susan Elizabeth
The nuclear envelope is a lipid bilayer that encases the genome and provides a physical boundary betweenthe cytoplasm and the nucleoplasm. While the nucleus is typically depicted as a sphere encircled by a smoothsurface of nuclear envelope, the smooth exterior can be interrupted by tubular invaginations of the nuclearenvelope into the deep nuclear interior. Such structures are termed the ?nucleoplasmic reticulum.?
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Han, Xianlin
Funded by
NIH-NATIONAL INSTITUTE ON AGING
Aging is the greatest known risk factor for Alzheimer's disease (AD), the most common cause of dementia inolder individuals. However, effective AD therapies remain elusive, which underscores the need to betterunderstand disease etiology and its co-occurrence with advanced age. The apolipoprotein E4 (apoE4) allele isthe strongest genetic risk factor for late-onset AD and it is associated with decreased lifespan. The apoEprotein is crucial to lipid homeostasis through its regulation of cholesterol, triglyceride and phospholipidmetabolism in the blood and the brain.