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Top viewed research performed by San Antonio Bioscience Organizations

Enhancing the Efficacy of a Chlamydia Subunit Vaccine Through
Encapsulation

Chlamydia trachomatis (CT) is the world's leading cause of sexually transmitted diseases (STD) and the most commonly reported STD in the U.S. and Texas. Chlamydia infection may result in pelvic inflammatory disease, complications such as ectopic pregnancy and infertility in women, in addition to epididymitis in men, pneumonia in infants, and even blindness. A peptide, or protein-based, vaccine candidate has been demonstrated to have a high degree of efficacy in two animal models of genital chlamydial infection.

Southwest Research Institute
XingGuo Cheng, Ph.D., a senior research scientist in SwRI’s Chemistry and Chemical Engineering Division
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Perturbation of antigen-specific T cell responses in latent TB/SIV co-infection

The major goal is to identify antigen-specific T cell responses in macaques with LTBI and SIV co-infection. Here we have infected some animals with Mtb to develop LTBI, while others naturally progress to ATB. Further, some of the animals have been co-infected with SIV (n=6) and 4 of which reactivated and 2 didn't. In the years to come we will focus on generating more LTBI, ATB, R, NR animals and also perform SIV ART treatment. Eventually antigen-specific responses to ESAT-6, CFP-10, and CW will be evaluated in the peripheral as well as lung samples. Role: MPI

Texas Biomedical Research Institute
Kaushal, Deepak
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