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San Antonio Medical Foundation

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Glioblastoma (GBM) is the most common and most aggressive of the primary malignant brain tumor in adults,with a median overall survival of 19.6 months following multi-modality therapy. The main limiting factor indelivering a tumoricidal radiation dose is the toxicity to surrounding brain. Therapeutic radionuclides, due to ashort tissue path and differences in radiobiology, have the potential to extend the therapeutic window for radiationin GBM.

UT Health San Antonio
Brenner, Andrew

The major goal of this project, using a model of Kawasaki disease in mice, is to selectively turn off the FSTL-1 gene at different times during the onset and development of the disease, and evaluate if, and how, FSTL-1 affects the heart damage seen in Kawasaki disease in order to develop an effective treatment strategy for Kawasaki disease's long term effects.

Texas Biomedical Research Institute
Patterson, Jean