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San Antonio Medical Foundation

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This renewal application stems from our successful first four years of a Bridge-to-the-Doctorate grant (SouthTexas Doctoral Bridge Program (STDBP; 2013-2017) supporting a partnership between the University ofTexas Health Science Center at San Antonio (UT Health San Antonio; PhD-granting) and Texas StateUniversity ? San Marcos (TxState, master's granting).

UT Health San Antonio
Oyajobi, Babatunde

The major goal of this proposal is to vaccinate neonatal macaques with recombinant, TLR-2 stimulating, BCG vaccine, which can induce central memory T cells, and thereby generate long-term immunity against tuberculosis. We will, therefore: 1) Evaluate TH1 immune responses induced by wild type and recombinant BCG vaccine in neonatal macaques; 2) evaluate efficacy of wild type and recombinant BCG vaccines against tuberculosis in neonatal macaques; and, 3) evaluate long-term efficacy of wild type and recombinant BCG vaccines using in neonatal macaques.

Texas Biomedical Research Institute
Gauduin, Marie-Claire