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San Antonio Medical Foundation

A Collaboration of the San Antonio Bioscience and Medical Research Community

A first-of-its-kind initiative between public and private sector to catalog and highlight Bioscience research in the city of San Antonio and the surrounding areas.

Trending Research

Top viewed research performed by San Antonio Bioscience Organizations

CV19: Blocking SARS-CoV-2 evasion from innate antiviral defenses

Basic Research

The University of Texas at San Antonio
McHardy, Stanton
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CONNECT: Synthesis of Highly Potent C-9 Artemisinin Derivatives for the Low-Cost Treatment of Artemisinin Resistant Malaria

Since its discovery from the extracts of sweet wormwood (Artemisia annua) in 1979. the anti-malarial drug artemisinin (3) is now the key starting material in the synthesis of life-saving artemisinin-based combination therapies (ACT). Yet. beginning in 2009. mutations in the parasites PfKelch13 protein began conferring artemisinin resistance in the Greater Mekong Subregion (GMS) (Figure 1).Since then. artemisinin resistance has been spreading and some ACT treatment failure rates have reached 26% to 46% in 2015.

The University of Texas at San Antonio
Frantz, Douglas
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