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Top viewed research performed by San Antonio Bioscience Organizations

DYSREGULATION OF TRANSPOSABLE ELEMENT SEQUENCES AS A NOVEL DISEASE MECHANISM IN ALZHEIMER'S DISEASE AND RELATED TAUOPATHIES
UT Health San Antonio
Frost,Susan Elizabeth
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THERAPEUTIC AGENTS TARGETING NUCLEAR RECEPTOR SIGNALING IN DISTINCT MOLECULAR SUBTYPES OF BREAST CANCER

Breast cancer (BC) has several distinct molecular subtypes, including estrogen receptor (ESR1) positive andtriple negative BC (TNBC). A significant proportion of ESR1-positive therapy sensitive-BCs (TS-BC) initiallyrespond to antiestrogens or aromatase inhibitors, but become therapy resistant-BCs (TR-BC) and progress toincurable metastases. Further, TNBC subtype has a more aggressive clinical course and lack targetedtherapies. Development of effective therapies for women with TR-BC and TNBCs represents the highest unmetneed.

UT Health San Antonio
Vadlamudi, Ratna K
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