Ca2+ is a critical second messenger that is required for several cellular processes. Cytosolic Ca2+ (cCa2+)transients are shaped by the mitochondria due to the highly negative membrane potential and through themitochondrial calcium uniporter (MCU). Mitochondrial Ca2+ (mCa2+) is utilized by the matrix dehydrogenases formaintaining cellular bioenergetics. Reciprocally, dysregulated elevation of cCa2+ under conditions of stroke,ischemia/reperfusion injury drives mCa2+ overload that in turn leads to mitochondrial permeability transition poreopening that triggers necrotic cell death.
A Collaboration of the San Antonio Bioscience and Medical Research Community
A first-of-its-kind initiative between public and private sector to catalog and highlight Bioscience research in the city of San Antonio and the surrounding areas.
Latest Projects
The University of Texas at San Antonio
The University of Texas at San Antonio
Southwest Research Institute
Southwest Research Institute
The University of Texas at San Antonio