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Top viewed research performed by San Antonio Bioscience Organizations


Stimulant abuse is a serious public health problem with untold medical, societal, and economic impactworldwide. Despite decades of research into the neurobiology of drug abuse, there are no FDA-approvedpharmacotherapies for stimulant abuse. One strategy to reduce the time required to get candidate medicationsinto the clinic is to repurpose drugs, already approved by the FDA for other indications, to treat stimulant abuse,and one strategy to improve the therapeutic effectiveness of a drug is to administer it in combination with seconddrug with a complimentary mechanism of action.

UT Health San Antonio
France, Charles Patrick

Endothelial dysfunction contributes to microvascular and macrovascular complications of diabetes. A major defense of endothelial cells against vascular injury is endothelial nitric oxide synthase (eNOS), which generates nitric oxide (NO) in the presence of optimal concentrations of the substrate L-arginine and the cofactor tetrahydrobiopterin (BH4). Diabetic nephropathy (DN) is associated with a state of progressive NO deficiency due to eNOS dysfunction, a phenomenon referred to as 'uncoupling'.

UT Health San Antonio
Gorin, Yves Claude