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Top viewed research performed by San Antonio Bioscience Organizations

OFFICE-BASED OPIOID TREATMENT SERVICES (OBT SRV)
UT Health San Antonio
Potter, Jennifer Sharpe
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DEGRADATION OF MITOCHONDRIAL INNER MEMBRANE PROTEIN DISRUPTS THE STRUCTURAL INTERACTION BETWEEN MITOFILIN AND CYCLOPHILIN D AND DETERMINES THE EXTENT OF ISCHEMIA/REPERFUSION INJURY

Disorders characterized by ischemia/reperfusion (I/R), such as myocardial infarction, stroke, andperipheral vascular disease, continue to be among the most frequent causes of devastating disease and maincauses of death in the US. Reperfusion of ischemic tissue triggers many pro-death signaling pathways whichconverge on to the mitochondria. Indeed, reoxygenation of cardiomyocytes leads to mitochondrial Ca2+overload and an increase in reactive oxygen species (ROS) generation that triggers the opening of themitochondrial permeability transition pore (mPTP).

UT Health San Antonio
Bopassa, Jean C
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