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San Antonio Medical Foundation

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Stimulant abuse is a serious public health problem with untold medical, societal, and economic impactworldwide. Despite decades of research into the neurobiology of drug abuse, there are no FDA-approvedpharmacotherapies for stimulant abuse. One strategy to reduce the time required to get candidate medicationsinto the clinic is to repurpose drugs, already approved by the FDA for other indications, to treat stimulant abuse,and one strategy to improve the therapeutic effectiveness of a drug is to administer it in combination with seconddrug with a complimentary mechanism of action.

UT Health San Antonio
France, Charles Patrick

<p>This is a multicenter, open-label, randomized phase II study which will enroll 112 newly diagnosed symptomatic multiple myeloma patients in a 1:1 fashion. Patients will be enrolled at approximately 20 centers in the United States.</p><p>Patients will undergo stem cell mobilization with plerixafor plus Granulocyte Colony Stimulating Factor (G-CSF), according to investigator discretion, after 4 cycles of induction therapy. Study treatment interruption for stem cell collection may not exceed 30 days.

Brooke Army Medical Center
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