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A Collaboration of the San Antonio Bioscience and Medical Research Community

A first-of-its-kind initiative between public and private sector to catalog and highlight Bioscience research in the city of San Antonio and the surrounding areas.

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Top viewed research performed by San Antonio Bioscience Organizations

EAGER: Reprogramming to the Totipotent State

Intellectual Merit. The totipotent state exists during a brief period of embryonic development soon after fertilization before implantation. In contrast to pluripotent embryonic stem cells (ESCs) or reprogrammed iPSCs, which have the potential to generate all embryonic tissue types, totipotent cells can produce both embryonic and extraembryonic tissues. To date, the totipotent state can be achieved by natural fertilization, or artificially by somatic cell nuclear transfer (aka cloning) or removal of epigenetic regulators in iPSCs.

The University of Texas at San Antonio
Gaufo, Gary
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Prolactin Regulation of Postoperative Pain in Males and Females

Despite recent advances in our understanding of pain mechanisms, there has been little-to-no overall improvement in the clinical management of postoperative pain. It is now recognized that effective postoperative pain management depends on key predictors, especially patient sex. Preclinical and clinical data indicate that, while postoperative pain levels show little-to-no sex-dependent dimorphisms, there are significant sex-based differences in analgesic efficacy, safety profile and abuse/addiction potential of current drugs used to treat postoperative pain.

UT Health San Antonio
Akopian, Armen N
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