Facilitated By

San Antonio Medical Foundation

Development of a live-attenuated vaccine platform against hemorrhagic fever causing arenaviruses

Texas Biomedical Research Institute

 

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Principal Investigator(s)
Martinez-Sobrido, Luis
Funded by
Department of Defense
Research Start Date
Status
Active

The central goal of this application is to demonstrate that recombinant forms of the prototypic mammarenavirus lymphocytic choriomeningitis virus (LCMV) containing a codon deoptimized (CD) nucleoprotein (NP) expressing glycoproteins (GP) of HF-causing LASV and JUNV (rLCMV/NPCD/GPHF) can be used for the development of a safe and protective individual or blended live-attenuated vaccine (LAV) to combat HF disease caused by LASV and JUNV infections.

Collaborative Project
Basic Research
Infectious Disease