Facilitated By

San Antonio Medical Foundation

Attenuation of Lassa virus via codon deoptimization

Texas Biomedical Research Institute

 

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Principal Investigator(s)
Martinez-Sobrido, Luis
Funded by
National Institutes of Health
Research Start Date
Status
Active

We propose to generate a recombinant LASV containing a codon deoptimized (CD) glycoprotein (GP) as a novel approach for the development of a LASV live-?attenuated vaccine (LAV). Moreover, rLASV/GPCD will provide us with a valid LASV surrogate that could be safely used in BSL2 facilities to facilitate the investigation of LASV by removing the obstacles posed by the requirement of BSL4 containment to work with live forms of LASV.

Collaborative Project
Basic Research
Infectious Disease