Facilitated By

San Antonio Medical Foundation

Characterization of 2-oxindole forming heme enzyme in the biosynthetic pathway of maremycins

The University of Texas at San Antonio

The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.

Principal Investigator(s)
Liu, Aimin
Funded by
Welch Fdn
Research Start Date

A2-oxindole forming heme enzyme. MarE. had been proposed as a fifth member pending structural validation.45 MarE is a functionally characterized monooxygenase that generates the oxindole moiety found in the biosynthetic pathways for maremycins (A - G). spirotryprostatin (A - B). and others. We will determine the crystal structure of MarE and revisit its catalytic function.

Collaborative Project
Basic Research
Infectious Disease