Facilitated By

San Antonio Medical Foundation

HIV-induced long non-coding RNA's in viral replication and immune response

Texas Biomedical Research Institute


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Principal Investigator(s)
Kulkarni, Smita V
Research Start Date

The majority of the human transcriptome consists of long non-coding RNAs (lncRNAs), which regulate the expression and function of protein coding genes, immune cell development, differentiation, and response to infections. The role of lncRNAs in HIV-infected cells and how the host lncRNAs impact the replication and persistence of HIV infection is not known. The objective of this proposal is to identify host lncRNAs that influence viral replication, cellular and immune responses to infection and molecular mechanisms of their action. Infections induce global changes in lncRNA expression and pathogens are believed to impact immune cell functions through differential induction of regulatory lncRNAs. Our preliminary data showed significant changes in cellular lncRNA expression

Collaborative Project
Basic Research
Infectious Disease