A Neonatal Monkey Model for Tuberculosis Vaccination
Principal Investigator(s)
Gauduin, Marie-Claire E.
Collaborating Institutions
Houston Methodist Research Institute
Funded by
National Institutes of Health
Research Start Date
Status
Active
Proposal:19-051 The major goal of this proposal is to vaccinate neonatal macaques with recombinant, TLR-2 stimulating, BCG vaccine, which can induce central memory T cells, and thereby generate long-term immunity against tuberculosis. We will, therefore: 1) Evaluate TH1 immune responses induced by wild type and recombinant BCG vaccine in neonatal macaques; 2) evaluate efficacy of wild type and recombinant BCG vaccines against tuberculosis in neonatal macaques; and, 3) evaluate long-term efficacy of wild type and recombinant BCG vaccines using in neonatal macaques. Role:Co-PI