The work proposed in this application is a pilot study. The data acquired will be used to build the rationale for a larger application (RO1) to the NIH-NEI. Overall, this study explores the use of a large non-human primate, specifically Baboon pluripotent stem cells to a derive RPC system for translational stem cell therapy investigations. The results obtained will allow for experimental treatment development for naturally occurring non-human primate (Baboon) retina degeneration identified in the local Baboon population. This work will be directly translational to humans.