The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Webster, Phillip Justin
Funded by
NIH
The Effects of Chronic mTOR Inhibition on Aging Muscle and Mitochondrial Function Sarcopenia is the age-dependent loss of skeletal muscle mass and function that begins early in adulthood and progresses into old age. These losses can increase the incidence of falls, morbidity, and severely impair the well-being of older people. The current therapies are insufficient to reverse these losses, so identifying key pathways could open up new therapeutic options which is particularly pressing given the rapid increase in the population of older people with the aging of the Baby Boom generation.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Griffith, Ann Venables
Funded by
NIH
T lymphocytes are critical mediators of immunity; however they are continuously lost for a variety of reasons throughout life, and therefore must be replaced. Generation of new T cells is the function of the thymus, and the unique stromal microenvironment in the thymus directs T cell development and the selection of self- tolerant, self-restricted T cell population. Unfortunately, the thymus undergoes a precipitous age-induced atrophy resulting in reduced naÔve T cell production.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Ipson, Brett
Funded by
NIH
Oxidative stress increases with age and likely contributes to a variety of age-related diseases, but the processes by which oxidative stress causes cellular damage and contributes to aging and its associated pathologies are not completely understood. This proposal seeks to study the role of atypical tyrosine isomers, which differ from endogenous tyrosine in the positioning of their hydroxyl group on the benzyl ring, in the harmful effects of oxidative stress.
As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Turner, Joanne
Funded by
National Institutes of Health
The goals of this program are: Project 1) Biology of the human lung mucosa in aging and tuberculosis; Project 2) Biology of alveolar macrophages in aging and tuberculosis; Project 3) Defining age-associated immune correlates of susceptibility to M. tuberculosis; and Project 4) Defining immune correlates of susceptibility to M. tuberculosis infection in the elderly" Txbiomed Project: 4696
