The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Curiel, Tyler J
Funded by
NIH-NATIONAL CANCER INSTITUTE
Collaborating Institutions
Technion
This proposal combines a team with expertise in aging, tumor immunology, tumor immunotherapy, specificgenetically modified animal models and early phase clinical trials with a computational team having greatexpertise in analyzing and modeling aging of the immune system.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Morilak, David A
Funded by
NIH-NATIONAL CANCER INSTITUTE
Cognitive impairment has a serious detrimental impact on the quality of life for prostate cancer survivorstreated by androgen deprivation therapy (ADT). Neuroimaging studies have shown structural and functionaldeficits in the medial prefrontal cortex (mPFC) and hippocampus (Hipp), which mediate higher order cognitiveprocesses, including cognitive flexibility and spatial cognition, that are impaired after ADT. In this project, we willinvestigate mechanisms that underly the cognitive impairments we have now shown to be induced by androgendeprivation in rats.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Lee, Sang
Funded by
NIH-GENERAL MEDICAL SCIENCES
Microhomology-mediated end joining (MMEJ) is an evolutionary conserved pathway to repair DNA doublestrand breaks (DSBs) by annealing small stretches (2-20 bps) of overlapping sequence (microhomology; MH)flanking the break site. By design, MMEJ is highly mutagenic because it always results in the deletion of oneof the MH and the inter-MH sequences. MMEJ also frequently leads to chromosomal rearrangements due toits ability to engage in promiscuous end joining.
