The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Iskra, Brian
Funded by
NIH-NATIONAL INSTITUTE ON AGING
As of 2014, there are approximately 14.5 million cancer survivors within the United States and this populationis projected to grow to 19 million by 2024. Cancer survivors exhibit an accelerated aging phenotype that ishypothesized to be a result of their exposure to chemotherapy. Despite the preponderance of evidencesuggesting that this accelerated aging phenotype happens, there are few basic science initiatives poised tostudy the underlying molecular mechanisms and their therapeutic implications.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Boyer, Thomas G
Funded by
NIH-CHILD HEALTH & HUMAN DEVELOPMENT
Collaborating Institutions
Chicago
Uterine leiomyomas (LM; fibroids) are monoclonal neoplasms of the myometrium (MM) and represent themost frequent tumors in women worldwide. Although benign, they nonetheless account for significantgynecologic and reproductive dysfunction.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Hu, Yanfen
Funded by
NIH-NATIONAL CANCER INSTITUTE
The tumor suppressor BRCA1 plays an important role in the homologous recombination (HR) pathwayof DNA double strand break (DSB) repair. From a mechanistic perspective, BRCA1 facilitates recruitment ofnucleases required for end resection, the commitment step in HR repair, yet paradoxically, BRCA1 has beenshown to inhibit the nuclease activity in vitro. It is unclear how nuclease-recruiting and -inhibiting activities ofBRCA1 can be reconciled in HR repair.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Li, Rong
Funded by
NIH-NATIONAL CANCER INSTITUTE
Most BRCA1-asociated breast tumors are basal-like, yet they originate from luminal progenitor cells.BRCA1 plays important roles in double strand break (DSB) repair and response to DNA replication stress.However, it remains a conundrum as to whether these ubiquitously important functions of BRCA1 are sufficientto account for its cell lineage-specific breast tumor suppression. Filling this longstanding intellectual disconnectcould inform more effective risk assessment and disease prevention.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Natarajan, Mohan
Funded by
NIH-OFFICE OF THE DIRECTOR
We are requesting funds to purchase a SARRP image-guided x-ray platform in order to continually support atotal of 26 research projects. Among the currently funded projects that requires the use of the irradiator, nine ofthem are NIH RO1, one PO1 and one U-42 projects. Additionally, one funded FDA approved phase1/2 study andfour NIH RO1 projects that are likely to get funded (currently under council review) proposed to use theirradiator.
