Uterine fibroids (UFs; leiomyomas) are the most important benign neoplastic threat to women's healthworldwide, but disproportionately affect women of color, particularly African American (AA) women, who have athreefold higher incidence rate and relative risk of UFs than Caucasian (CC) women. While the underlyingcause for this risk disparity is not fully understood, recent studies implicate hypovitaminosis D as a majorcontributor.

Advancing the Science of Cancer in LatinosProject Summary/AbstractThe proposed conference, ?Advancing the Science of Cancer in Latinos,? would occur February21-23, 2018, in San Antonio, Texas.

Self-renewing tumor-propagating cells drive continued tumor growth and are responsible for relapse. If the processby which tumor cells self-renew could be turned off, then tumors would regress and patients would remain relapsefree. The goal of this updated proposal is to define the cellular and molecular mechanisms by whichNotch regulates tumor-propagating potential and plasticity of the tumor propagating cell state inembryonal rhadomyosarcoma (ERMS), a devastating pediatric malignancy of the muscle.

This exploratory project is directed towards understanding the biological role of a novel oncogenic driver inEwing sarcoma. Ewing sarcoma is an aggressive cancer of bone and soft tissues in children with poor long-term outcome. It is characterized by the chromosomal translocation generating a fusion oncogene betweenEWS and an Ets family transcription factor, most commonly FLI-1. EWS-FLI-1 translocation accounts for 85%of Ewing sarcoma cases.