As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Ebrahimi, Diako
Clinical data indicate that people with heart-related diseases and other underlying medical conditions are at a significantly higher risk for COVID-19. Many of these underlying diseases have genetic sources. Importantly, susceptibility to artery diseases are linked to multiple SNPs within FURIN, which encodes a cell membrane-bound protease known as Furin. Studies suggest that Furin can cleave the SARS-CoV-2 Spike (S) protein to facilitate/enhance viral entry into human alveolar type II cells.
As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Martinez-Sobrido, Luis
Funded by
San Antonio Partnership for Precision Therapeutics
Collaborating Institutions
University of Texas Health Science Center San Antonio
We aim to determine the structural basis of RNA processing in host immune and inflammatory response critical for viral survival and growth and will conduct HTS screening, medicinal chemistry, and in vitro and in vivo studies towards rapid clinical translation.
As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Kaushal, Deepak
Collaborating Institutions
Washington University in St. Louis
The major goal is to generate ATB in animals and perform experiments aimed at depleting MDSCs to look at the impact in clinical, microbiological and immunological terms.
As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Kaushal, Deepak
Funded by
National Institutes of Health
The goal of this project is to support research by expanding ABSL3 primate capabilities.
The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.
Principal Investigator(s)
Hung, Chiung-Yu
Funded by
Mira Vista Diagnostics, LLC
The goal of this project is to develop a standardized test that measures immune cellular response to Coccidioides antigens. This assay is useful in a variety of clinical scenarios. It could serve as a diagnostic test for active CM. an indicator of whether or not prophylactic antifungal therapy is needed. a marker of severe infection with disseminated disease and/or a correlate of prolonged antifungal therapy.
As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Martinez-Sobrido, Luis
Funded by
San Antonio Partnership for Precision Therapeutics
Collaborating Institutions
University of Texas Health Science Center San Antonio
We aim to develop a high-throughput fluorescent assay of Orf10-CUL2 binding; identify candidate inhibitors of Orf10-CUL2 binding by computational screening; evaluate impact of these molecules on SARS-CoV-2 replication in cell-based assays and in the mouse model; and develop medicinal chemistry infrastructure for optimization of Orf10 inhibitors.
59th Medical Wing at the Wilford Hall Ambulatory Surgical Center (WHASC)
The 59th Medical Wing Chief Scientist provides the strategic vision, direction, oversight, project management support and technical resources to advance medical modernization efforts with a unique focus on research activities.
59th Medical Wing at the Wilford Hall Ambulatory Surgical Center (WHASC)
The 59th Medical Wing Chief Scientist provides the strategic vision, direction, oversight, project management support and technical resources to advance medical modernization efforts with a unique focus on research activities.
As one of the world’s leading independent biomedical research institutions, Texas Biomedical Research Institute is dedicated to advancing the health of our global community through innovative biomedical research.
Principal Investigator(s)
Martinez-Sobrido, Luis
Funded by
University of Texas Health Science Center at San Antonio
Collaborating Institutions
University of Texas Health Science Center San Antonio
We propose to investigate SARS-CoV-2 and identify key molecular interfaces in RSP complex for their immunogenic disruption. Additionally, we will conduct in vitro and in vivo testing of peptides for immunogenic molecular disruption.
59th Medical Wing at the Wilford Hall Ambulatory Surgical Center (WHASC)
The 59th Medical Wing Chief Scientist provides the strategic vision, direction, oversight, project management support and technical resources to advance medical modernization efforts with a unique focus on research activities.
