The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Singh, Brij B
Funded by
NIH-DENTAL & CRANIOFACIAL RESEARCH
Saliva performs a number of extremely important biological functions that are instrumental in maintaining oralhealth. It has been estimated that more than 5 million people in the US suffers from salivary gland dysfunction(Sjogren's syndrome). Although no genes mutations have been identified that could explain the pathogenesisof Sjogren's syndrome (SS), recent evidence have suggested that T17-cell infiltration and induction ofapoptosis in salivary gland acinar cells could be the two major events that could lead to salivary glanddestruction.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Khan, Crystal
Funded by
NIH-GENERAL MEDICAL SCIENCES
Phenylalanine hydroxylase (PheH) catalyzes the hydroxylation of dietary phenylalanine to tyrosine. Lack of a functional PheH results in the metabolic disease phenylketonuria (PKU). PheH is one of three aromatic amino acid hydroxylases; the other two are tyrosine hydroxylase and tryptophan hydroxylase. Regulation of PheH is tightly controlled so that only excess phenylalanine is consumed. The enzyme is regulated by activation by phenylalanine, inhibition by tetrahydrobiopterin (BH4), and phosphorylation at Ser16.
