The major goal is to study the role of ILC3 type cells in the mucosal immunity to Mtb infections in macaques. Role: Sub-PI

19-050 The major goal is to share the samples collected from the various cohorts of NHPs exhibiting latent as well as reactivation TB. Additionally, we will continue to perform data analysis on previous studies performed during the UH2 portion of the study. Role: MPI

The major goal is study if multiple antigen presenting system (MAPS) can effectively boost BCG vaccination responses to protect macaques against lethal Mtb challenge. Role: Sub-PI

19-053 The major goal is to develop reagents for and to identify antigen-specific T cell responses in macaques with persistent and cured LTBI. In the first three years of this program project we have infected 12 macaques with ultra low-dose of Mtb to generate LTBI, and developed a model for LTBI clearance by treating half the animals with INH/RIF weekly regimen for 12 weeks. We will now study correlates of clearance in INH/RIF treated and untreated animals using banked PBMCs, stimulated BAL and lung cell samples.

Increased inflammation affects the immune response to Mycobacterium tuberculosis (M.tb) infection in old and young mice in ways not yet understood. The project objective is to determine the mechanisms in which inflammation influences the response to early M.tb infection in young and old mice. The goal of the project is to determine ways inflammation can be modulated with anti-inflammatory treatment to improveM.tb infection outcome in young and old mice, and to apply this knowledge to benefit tuberculosis disease outcome in elderly persons and persons with increased inflammation.

Fellowship for Colwyn Headley.

The goal of this research project is to perform Ebola infected PK/PD qPCR analysis for the efficacy study of mAb therapeutic against EBOV lethal challenge in rhesus macaques.

We propose a strategy of host derived IL-10 modulation, strictly at the time of vaccination for generating a qualitatively different set of T cells resulting in sustained long-term protection against M.tb infection in mice.

This program will test the immunogenicity and efficacy of a novel HIV vaccine.

In this multidisciplinary proposal we will use a nonhuman primate model of Parkinsons disease to study the reversibility of the beneficial effects of physical exercise and its impact on induced pluripotent stem cell (iPSC)-based therapy. We will investigate how exercise and iPSC-based cell therapy reinnervate the striatum and restore movement and gait by recruiting new neural networks as revealed by longitudinal multimodal imaging, behavioral and morphological analysis.