The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.
Principal Investigator(s)
McHardy, Stanton
Funded by
Univ of TX HSC at San Antonio 745
The systemic inflammatory response in sepsis has devastating consequences resulting in high morbidity and mortality. Over the past decade. mortality from sepsis alone has remained greater than 25%. despite effective antimicrobial therapy. In particular. the survival rate of the Hispanic population with other complications and combat casualties are often poorer. This highlights lack of understanding of the pathways operative in sepsis and the necessity for improved therapies. One of the major changes that occur during Multi-organ-failure (MOF) in severe sepsis is mitochondrial dysfunction.
The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.
Principal Investigator(s)
McHardy, Stanton
Funded by
Univ of TX HSC at San Antonio 745
The overall goal of this collaborative proposal is to investigate whether inhibition of SAMHD1 can be used to potentiate effectiveness of cytarabine in treatment of AML. ALL and other childhood and adult cancers.UTSA and Dr. McHardy???s lab will provide all of the synthesis and medicinal chemistry support for this collaborative proposal.In Aim 1 we will follow up on any identified hits from the high-throughput screening efforts carried out at UT Health SA in the CIDD core facility.This will include the re-synthesis of the hit compounds to confirm structure. purity and SAMHD1 activity.
The University of Texas at San Antonio is an emerging Tier One research institution with nearly 29,000 students.
Principal Investigator(s)
Romero Uribe, Gabriela
Ye, JingYong
Funded by
NIH Natl Inst of Neuro Disorder/Stroke
Cell-type specific manipulation of neural circuits is required for the treatment of neurological disorders such as epilepsy and autism. Existing technologies to control neural activity offer limited possibilities. Manipulation of brain circuits via direct drug treatment is restricted by the selective permeability of the blood-brain barrier. the rapid clearance of cerebral fluids and the lack of specificity. which results in poor response to drugs and undesirable side effects.
