The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Lococo, Peter
Funded by
NIH-DIABETES/DIGESTIVE/KIDNEY DISEASES
Type 2 diabetes (T2D) afflicts nearly 30 million individuals in the US, with at least 50% suffering from neurologicalcomplications that comprise diabetic neuropathy (DN). The metabolic changes in T2D produce substantialperipheral nerve damage that manifests commonly as debilitating numbness and neuropathic pain. Progressionof the nerve damage often leads to loss of sensation that can compromise patients? ability to execute daily tasksand care for themselves, while also increasing risk of severe injury.
The UT Health San Antonio, with missions of teaching, research and healing, is one of the country’s leading health sciences universities.
Principal Investigator(s)
Flores, Shahida K
Funded by
NIH-GENERAL MEDICAL SCIENCES
Endocytosis is a conserved pathway that internalizes macromolecules and transmembrane proteins and sortsthem through the endo-lysosomal system to their destinations. This process is often dysregulated in manydiseases including cancers, metabolic disorders and neurodegenerative diseases. Elucidating the endocyticmechanisms of transmembrane proteins will improve our understanding of biological processes, diseaseprognosis and therapeutic strategies.
