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San Antonio Medical Foundation

Trending Research

Top viewed research performed by San Antonio Bioscience Organizations


The long-term goal of this research project is to understand the role of scaffolding proteins in the regulation ofopioid receptors. Opioids are commonly administered as systemic analgesics to treat acute, chronic, andintractable pain syndromes. However, activation of mu opioid receptors (MOPr) throughout the central nervoussystem produces negative side effects that often contraindicate continued use.

UT Health San Antonio
Jeske, Nathaniel Aaron

Chronic stress is a factor in many psychiatric diseases, such as depression, PTSD and other anxiety disorders. The brain noradrenergic (NE) system is important in arousal and acute stress reactivity, and is implicated in the etiology of stress-related psychiatric disorders. In the previus grant period, we showed that increasing NE transmission acutely in the prefrontal cortex (PFC) of rats facilitates cognitive flexibility on an attentional setshifting test (AST). By contrast, chonic unpredictable stress (CUS) compromised cognitive flexibility.

UT Health San Antonio
Morilak, David A