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A Collaboration of the San Antonio Bioscience and Medical Research Community

A first-of-its-kind initiative between public and private sector to catalog and highlight Bioscience research in the city of San Antonio and the surrounding areas.

Trending Research

Top viewed research performed by San Antonio Bioscience Organizations

The Cyclic Amp/Phosphodiesterase4 Axis Regulates Proximal B Cell Receptor Signaling and Offers a New Therapeutic Strategy for B

Aberrant activation of the B cell receptor (BCR) is an emerging hallmark of mature B cell tumors. The BCR initiates a signaling cascade that activates multiple kinases, including SYK, BTK and PI3K?, leading to engagement of the NF-?B, PI3K/AKT, RAS and MAPK pathways, thus promoting proliferation/survival of B cells. Considering this pro-growth outcome, it is not surprising that malignant B cells hijack this signaling module for their benefit.

UT Health San Antonio
Cooney, Jeffrey
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CRISPR-based RNA targeting for HIV intervention

Human Immunodeficiency Virus (HIV) persists in the form of a ???latent reservoir??? hiding from complete eradication by the immune system or antiretroviral drugs. Current drugs eliminate actively multiplying HIV but are unable to eradicate the latent virus. Therefore. we hypothesize that a successful HIV RNA targeting strategy will efficiently and simultaneously target multiple conserved sites in HIV transcript. the possibility of concurrent alterations to which will either be negligible or entail fitness cost to the virus.

The University of Texas at San Antonio
Wang, Yufeng
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