Cell-type specific manipulation of neural circuits is required for the treatment of neurological disorders such as epilepsy and Parkinson’s disease. Precise control of neural circuits will enable the development of neuromodulation therapies for these debilitating conditions. Existing technologies to control neural activity offer limited possibilities.

Many genes including those associated with viral infections undergo differential splicing in different human populations. The aim of this study is to identify and quantify these differences and investigate their role in differential antiviral immunity among human populations.

The major goal of this project is to use a new tool like CRISPR/Cas13d to cleave HIV RNA. An HIV RNA-targeting strategy that efficiently and simultaneously targets multiple conserved sites , will result in the eradication of HIV from the cells.

In 2017, an estimated 10 million people developed TB disease, demonstrating an urgent need for new approaches to therapy, including host-directed therapy (HDT), to halt infection and progression of active TB. To this end, the overall goal of our ongoing research program is to identify intracellular ?master regulators? of inflammation and metabolic intermediates that dictate human macrophage responses to Mycobacterium tuberculosis infection as a strategy to identify potential host cell targets for HDT.

Presidents of San Antonio’s four largest research institutions today announced they are providing $800,000, collectively, for a major initiative in precision therapeutics. The process of precision therapeutics ultimately leads to breakthrough treatments that can be individualized to specific patient populations.

Southwest Research Institute has received new funding from the Medical Technology Enterprise Consortium (MTEC) and the Food and Drug Administration (FDA) to use an SwRI-developed bioreactor to propagate cells for personalized regenerative medicine applications. A $3 million MTEC program will demonstrate stem cell manufacturing, and a $2.3 FDA contract is funding CAR T-cell production.

The nuclear envelope is a lipid bilayer that encases the genome and provides a physical boundary betweenthe cytoplasm and the nucleoplasm. While the nucleus is typically depicted as a sphere encircled by a smoothsurface of nuclear envelope, the smooth exterior can be interrupted by tubular invaginations of the nuclearenvelope into the deep nuclear interior. Such structures are termed the ?nucleoplasmic reticulum.?