The overall goal of this Fast-Track SBIR project is to evaluate the real-world adoption of KIOS, a patient-centered digital therapeutic / mobile app to assist in the effective self-management of Opioid Use Disorder (OUD). Previous work demonstrated that KIOS could chart the trajectories of patients with OUD by tracking concurrent changes in multiple clinical measures as they interact. KIOS makes it possible to process patient-entered data and provide responsive behavioral advice to patients specific to their condition in real time.

Traumatic brain injury (TBI) impacts 2.5 million people in the U.S. annually. Most people will sustain mild TBI (mTBI). with approximately 13% experiencing chronic cognitive symptoms impacting quality of life. Individuals with mTBI report experiencing sub-clinical deficits in language that include difficulty with starting. maintaining. and following conversations. However. these symptoms are mostly self-reported and elusive using existing clinical tools. Language comprehension demands the efficient construction of a coherent message from a rapid stream of input.

The primary objective of this study is to evaluate the effect of OCA compared to placebo on histological improvement in nonalcoholic steatohepatitis (NASH) by assessing the following primary endpoints using NASH Clinical Research Network (CRN) scoring criteria: Improvement in fibrosis by at least 1 stage with no worsening of NASH, or Resolution of NASH with no worsening fibrosis

Basic Research

A2-oxindole forming heme enzyme. MarE. had been proposed as a fifth member pending structural validation.45 MarE is a functionally characterized monooxygenase that generates the oxindole moiety found in the biosynthetic pathways for maremycins (A - G). spirotryprostatin (A - B). and others. We will determine the crystal structure of MarE and revisit its catalytic function.

Traumatic brain injury (TBI) and many other brain diseases/injuries exhibit sex differences in prevalence. onset. and outcomes. Some of these differences are attributed to the fact that the human brain is sexually dimorphic and there are certain regional and structural differences that exist between male and female brains. However. the effect of these sex variations in biomechanical responses of brain have not been elucidated. The paucity of sex-specific knowledge in brain biomechanics and TBI fields is mainly due to the fact that. these fields have predominantly focused on males.

SUMMARY: 16 MAR 2018Delays in PFC contribute to increased fluid losses and nutritional demands, abdominal wall hernias, enterocutaneous fistula, and intra-abdominal infections.Hypothesis: The use of HTS after DCL may decrease the time to PFC and reduce the number of complicationsThis study will examine ten (10) flights of approximately 50 adult USAF basic military trainees (BMTs) each, 5 female and 5 male flights.