Inecalcitol is a vitamin D receptor (VDR) agonist, a chemically modified analogue of calcitriol the active form of natural Vitamin D3. Inecalcitol is a novel synthetic vitamin D analogue developed by Hybrigenics. Inecalcitol was found to be 10 times more potent and 100 times less toxic than calcitriol. In addition to their well-known effects on calcium and phosphate homeostasis, calcitriol and VDR agonists are being increasingly recognized for their potent role in cell proliferation, differentiation, and immunomodulation.
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The University of Texas at San Antonio
The University of Texas at San Antonio
Southwest Research Institute
Southwest Research Institute
The University of Texas at San Antonio
The University of Texas at San Antonio