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Top viewed research performed by San Antonio Bioscience Organizations

Taccalonolides: Mechanisms of Action and Cellular Resistance

Microtubule stabilizers are valuable drugs used in the treatment of cancer. The focus of this project is a new class of plant-derived microtubule stabilizers, the taccalonolides. The taccalonolides have distinct effects on interphase microtubule bundling, mitotic spindle morphology and mitotic signaling pathways. Potent new taccalonolides have been identified for the first time and they robustly polymerize purified tubuli indicating a direct interaction with tubulin/microtubules.

UT Health San Antonio
Mooberry, Susan L
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Exploring the impact of inflammaging on immune function during M. tb infection

Age-associated changes in immune function in old age are a known risk factor for tuberculosis (TB) however. the contribution of the heightened systemic inflammatory state (inflammaging) often observed in elderly individuals has not been previously considered. In Aim 1 we hypothesize that inflammation in the periphery will serve as a predictive biomarker of pulmonary inflammation and susceptibility to M.tb infection in old age.

The University of Texas at San Antonio
Wang, Yufeng
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