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While great advances have been made into understanding the biomechanical environment within human joints, large gaps in our knowledge of the basic mechanics still exist. These gaps are a direct result of limitations in our ability to experimentally characterize detailed internal joint mechanics during in vivo human motion. This lack of fundamental knowledge underlies a multitude of basic and applied research areas in musculoskeletal biomechanics.

Southwest Research Institute
Travis Eliason; Andrew Moore

Transposable elements, known colloquially as ?jumping genes,? constitute approximately 45% of the humangenome. Cells utilize epigenetic defenses to limit transposable element jumping, including formation of silencingheterochromatin and generation of piwi-interacting RNAs (piRNAs), small RNAs that facilitate clearance oftransposable element transcripts. Transposable element activation has recently been identified as a keymediator of neuronal death in tauopathies, a group of neurodegenerative disorders that are pathologicallydefined by deposits of tau protein in the brain.

UT Health San Antonio
Frost, Susan Elizabeth