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San Antonio Medical Foundation

A Collaboration of the San Antonio Bioscience and Medical Research Community

A first-of-its-kind initiative between public and private sector to catalog and highlight Bioscience research in the city of San Antonio and the surrounding areas.

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Top viewed research performed by San Antonio Bioscience Organizations

INVESTIGATING THE ROLE OF TRANSPOSABLE ELEMENT DYSREGULATION AS A DRIVER OF NEUROTOXICITY IN TAUOPATHY

Transposable elements, known colloquially as ?jumping genes,? constitute approximately 45% of the humangenome. Cells utilize epigenetic defenses to limit transposable element jumping, including formation of silencingheterochromatin and generation of piwi-interacting RNAs (piRNAs), small RNAs that facilitate clearance oftransposable element transcripts. Transposable element activation has recently been identified as a keymediator of neuronal death in tauopathies, a group of neurodegenerative disorders that are pathologicallydefined by deposits of tau protein in the brain.

UT Health San Antonio
Frost, Susan Elizabeth
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A Randomized, Phase II Trial Evaluating the Efficacy and Safety of Lenalidomide, Bortezomib and Dexamethasone (RVD) with or Without Panobinostat in Transplant Eligible,Newly Diagnosed Multiple Myeloma.

<p>This is a multicenter, open-label, randomized phase II study which will enroll 112 newly diagnosed symptomatic multiple myeloma patients in a 1:1 fashion. Patients will be enrolled at approximately 20 centers in the United States.</p><p>Patients will undergo stem cell mobilization with plerixafor plus Granulocyte Colony Stimulating Factor (G-CSF), according to investigator discretion, after 4 cycles of induction therapy. Study treatment interruption for stem cell collection may not exceed 30 days.

Brooke Army Medical Center
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