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San Antonio Medical Foundation

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Mechanical loading experienced by skeletal tissues plays an important role in bone formation and remodeling.Osteocytes are the most abundant bone cell type and the major mechanosensory cells of the bone. Theyorchestrate bone remodeling from their location throughout bone matrix by coordinating osteoblastic formationand osteoclastic resorption. Osteocytes are connected to neighboring osteocytes and other bone cells via gapjunction channels and to extracellular environments via hemichannels. Both types of channels are formed byconnexin (Cx) 43.

UT Health San Antonio
Jiang, Jean X