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Schizophrenia remains one of the most disabling conditions world-wide with an economic burden thatexceeded $155 billion dollars in fiscal year 2013 alone. Despite existing medication and community treatment,many individuals with this diagnosis continue to have poor outcomes and struggle toward recovery.

UT Health San Antonio
Velligan, Dawn I

Inhibition of the renal SGLT2 transporter has proven to be an effective therapeutic interventionto reduce plasma glucose levels and HbA1c in type 2 diabetic patients. The glycemic-loweringefficacy of the SGLT2 inhibitors results from two distinct mechanisms: (i) induction ofglucosuria, which amounts to ~70-90 grams per day and (ii) amelioration of glucotoxicity leadingto increased insulin sensitivity in muscle and improved beta cell function (JCI 124:509-514,2014).

UT Health San Antonio
DeFronzo, Ralph A