Genetic studies, first done in model eukaryotes and more recently in mammals, have revealed thathomology-directed DNA repair (HDR) plays a critical role in the elimination of DNA double-strandbreaks and in the preservation of stressed or injured DNA replication forks. HDR is reliant on the tumorsuppressors BRCA1-BARD1, BRCA2, and PALB2, mutations in which cause breast, ovarian, and othercancers.
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The University of Texas at San Antonio
The University of Texas at San Antonio
Southwest Research Institute
Southwest Research Institute
The University of Texas at San Antonio
The University of Texas at San Antonio