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San Antonio Medical Foundation

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Chronic liver disease is the fifth leading cause of mortality in American Indian (AI) and Alaska Native populations. There are currently no data available on the development of fatty liver disease (steatosis) and fibrosis, early manifestations of chronic liver disease, in AI. Metabolic disease and alcohol are each associated with fatty liver disease, but their relative impact on its presence and severity are unknown.

Texas Biomedical Research Institute
Cole, Shelley

The primary objective of this study is to evaluate the effect of OCA compared to placebo on histological improvement in nonalcoholic steatohepatitis (NASH) by assessing the following primary endpoints using NASH Clinical Research Network (CRN) scoring criteria: Improvement in fibrosis by at least 1 stage with no worsening of NASH, or Resolution of NASH with no worsening fibrosis

Brooke Army Medical Center
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