Facilitated By

San Antonio Medical Foundation

A Collaboration of the San Antonio Bioscience and Medical Research Community

A first-of-its-kind initiative between public and private sector to catalog and highlight Bioscience research in the city of San Antonio and the surrounding areas.

Trending Research

Top viewed research performed by San Antonio Bioscience Organizations

SGLT2 INHIBITION AND STIMULATION OF ENDOGENOUS GLUCOSE PRODUCTION

Inhibition of the renal SGLT2 transporter has proven to be an effective therapeutic interventionto reduce plasma glucose levels and HbA1c in type 2 diabetic patients. The glycemic-loweringefficacy of the SGLT2 inhibitors results from two distinct mechanisms: (i) induction ofglucosuria, which amounts to ~70-90 grams per day and (ii) amelioration of glucotoxicity leadingto increased insulin sensitivity in muscle and improved beta cell function (JCI 124:509-514,2014).

UT Health San Antonio
DeFronzo, Ralph A
More Info
ANTIFUNGAL RESISTANCE GENE TARGETING IN CANDIDA GLABRATA BY TARGET CAPTURE

Most of what we know about antifungal drug research is derived from studies of non-pathogenic model fungi,such as Saccharomyces cerevisiae, which can easily be inserted into high throughput screening platforms,but are unsuitable as pan-fungal models. The rapid completion of genome sequences, and continuallyevolving bioinformatic manipulation of this vast and growing amount of data, has enabled new approaches toantifungal investigation.

UT Health San Antonio
Wickes, Brian L
More Info