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Obesity is a major risk factor for type II diabetes and metabolic syndromes. Increased understanding ofbody weight regulation may lead to effective strategies to combat obesity and diabetes. Hypothalamicneurons, including anorexigenic pro-opiomelanocortin (POMC) neurons and orexigenic Agouti-relatedpeptide (AgRP) neurons, integrate multiple metabolic cues (e.g. leptin and insulin) to provide a coordinatedcontrol of energy and glucose homeostasis.

UT Health San Antonio
Liu, Feng