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San Antonio Medical Foundation

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Oxidative stress causes mitochondrial dysfunction in obesity and type 2 diabetes mellitus (T2DM), but the molecular mechanisms underlying the cause remain poorly elucidated. Cardiolipin (CL) is a mitochondrial membrane phospholipid required for oxidative phosphorylation and mitochondrial biogenesis. The biological function of CL is determined by its acyl composition, which is dominated by linoleic acid in healthy metabolic tissues.

UT Health San Antonio
Shi, Yuguang

This is a Phase 3 Randomized Study to Assess the Efficacy and Safety of Ublituximab in Combination with Ibrutinib Compared to Ibrutinib Alone, in Patients with Previously Treated High-Risk Chronic Lymphocytic Leukemia (CLL). Will evaluate the effect of the addition of ublituximab to ibrutinib on overall response rate (ORR = CR + PR) in all study patients who are evaluable for efficacy assessment after the 200th study patient is enrolled across all sites.

Brooke Army Medical Center
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