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This competing renewal of our longitudinal project proposes to elucidate mechanisms driving the initiationand progression of substance use is consistent with NIDA and NIMH's recently outlined strategic plans (NIDA,2016; NIH CRAN, 2015; NIMH, 2015) prioritizing research on the period between adolescence and youngadulthood. Defining features of typical adolescent development are increases in sensation seeking followed bymore gradual increases in impulse control (described by the Dual Systems model).

UT Health San Antonio
Dougherty, Donald M

Prescription opioids (mu opioid receptor agonists) are the drugs of choice for treating moderate to severe pain,despite well-documented adverse effects of those drugs (e.g., abuse, respiratory depression) and significantpublic health concerns. Mu opioids are the most widely abused of all prescription medications and fataloverdoses have reached epidemic levels. Thus, there is a dire need for more effective treatments for pain withfewer deleterious effects.

UT Health San Antonio
Minervini, Vanessa