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The major goal of the contract is to provide infrastructure support for the continuation of the Strong Heart Study including oversight of its data and samples. Dr. Cole will director the Strong Heart Study Genetics center and Chair the Strong Heart Study Steering Committee.

Texas Biomedical Research Institute
Cole, Shelley A.

Morbidity and mortality associated with human mammarenavirus infections involve a failure of the host's innate immune response to restrict virus multiplication at early stages of infection, thus compromising the initiation of an effective innate and adaptive immune response to control and eliminate the virus. Studies in this application will provide a better understanding of arenavirus-host innate defense interactions, which can facilitate the development of novel strategies to combat human pathogenic mammarenaviruses.

Texas Biomedical Research Institute
Martinez-Sobrido, Luis