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Trending Research

Top viewed research performed by San Antonio Bioscience Organizations

Administrative Supplement to Heme-Dependent Chemistry in Tyrosine Oxidation (R01GM108988)

Basic Research

The University of Texas at San Antonio
Liu, Aimin
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DISSECTING ALLOSTERY IN PYRUVATE KINASE

This research project will seek to answer if the allosteric site in one subunit regulates the active site in the same subunit. a result that will simplify mechanistic interpretation of structural changes. Detailed understanding of the molecular mechanisms of hL-PYK will facilitate future drug designs to activate (or prevent inhibition of) this enzyme to reduced hepatic glucose secretion and counteract hyperglycemia.In both type 1 and type 2 diabetes. hepatic secretion of glucose is a primary contributor to hyperglycemia. In turn.

The University of Texas at San Antonio
Lamb, Audrey
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