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Deep Hypothermia
59th Medical Wing at the Wilford Hall Ambulatory Surgical Center (WHASC)
Chagoy
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Fractalkine-mediated neuronal protection in the diabetic retina

In the diabetic retina disruption of fractalkine (FKN) signaling induces fibrin(ogen) deposition. increased production of IL-1??? by microglia. vascular and neuronal damage.But. how FKN and its receptor. CX3CR1. regulate microglia activation and retinal pathology is unknown.In humans. two single nucleotide polymorphisms in the CX3CR1 locus (hCX3CR1-I249/M280) that show defective binding to FKN. play a key role in inflammation during diabetes.Induction of diabetes in a mouse model expressing the human CX3CR1-I249/M280 revealed accelerated neuronal loss in the retina.

The University of Texas at San Antonio
Cardona, Astrid
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