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The major goal of the contract is to provide infrastructure support for the continuation of the Strong Heart Study including oversight of its data and samples. Dr. Cole will director the Strong Heart Study Genetics center and Chair the Strong Heart Study Steering Committee.

Texas Biomedical Research Institute
Cole, Shelley A.

Our long-term goal is to understand the mechanism and function of the ubiquitin- proteasome system in health and disease. This proposal focuses on the function of the XPC-Rad23 complex in DNA damage response and proteolysis. Mutations in XPC protein lead to a genetic disorder Xeroderma pigmentosum (XP) that exhibits extreme sunlight sensitivity and a strong propensity for skin cancer. XPC was known previously as a key DNA repair factor that cells employ to protect from sunlight-inflicted DNA injury.

UT Health San Antonio
Rao, Hai