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Saliva performs a number of extremely important biological functions that are instrumental in maintaining oral health. It has been estimated that more than 5 million people in the US suffers from salivary gland dysfunction. Secretion of saliva is driven by concerted activities of a number of ion channels and transporters. Although, it is believed that calcium is the primary intracellular factor that regulates fluid secretion, the molecular mechanism involved in the regulation of cytosolic calcium is not clearly understood.

UT Health San Antonio
Singh, Brij B

Oral health is associated with nutritional intake and overall well-being in elderly populations and progressivelydeteriorates with aging. In addition, salivary gland function, which plays a major role in oral defense, alsodecreases with age. However, the mechanisms involved in this age-related decline have not beencomprehensively studied due to a lack of proper laboratory animal models for studying changes in oral healthwith aging. The common marmoset is a relatively short-lived non-human primate (NHP) that recapitulates manyof the physiological changes that occur in human aging.

UT Health San Antonio
Yeh, Chih-Ko