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San Antonio Medical Foundation

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The major goal of this project, using a model of Kawasaki disease in mice, is to selectively turn off the FSTL-1 gene at different times during the onset and development of the disease, and evaluate if, and how, FSTL-1 affects the heart damage seen in Kawasaki disease in order to develop an effective treatment strategy for Kawasaki disease's long term effects.

Texas Biomedical Research Institute
Patterson, Jean

Q fever is a worldwide zoonotic disease that is caused by the obligate intracellular Gram-negative bacterium, Coxiella burnetii. Human Q fever can develop into a severe chronic, potentially fatal disease. However, there is no vaccine commercially available for prevention of human Q fever in the US. Additionally, it is difficult to treat chronic Q fever patients with various antibiotic regimens. Therefore, there is an urgent need to develop an emergency alternative prophylactic and therapeutic strategy for prevention and treatment of Q fever.

The University of Texas at San Antonio
Zhang, Guoquan