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Acute coagulopathy is a major complication affecting both soldiers and civilians sustaining traumatic injuries. Human Platelet Derived Hemostatic Agents (PDHAs) have been developed in an attempt to improve hemostatic capabilities for patients experiencing coagulopathies related to platelet deficit or dysfunction. These products are expected to be particularly vital to soldiers injured on the front lines, where medical facilities are not readily available. One PDHA currently being considered for use by the U.S.

Naval Medical Research Unit San Antonio (NAMRU-SA)
CDR Forest R. Sheppard, MD FACS, U.S. Navy

Coxiella burnetii is an obligate intracellular Gram-negative bacterium that causes acute and chronic Q fever in humans. It is an understudied category B select agent and can be transmitted via aerosol. The existing formalin-inactivated phase I whole-cell vaccine (PIV) induces serious side effects in previously sensitized individuals and no vaccine is commercially available for prevention of human Q fever in the US. Therefore, creation of a safe and effective vaccine to prevent Q fever remains an important public health and national biosecurity goal.

The University of Texas at San Antonio
Zhang, Guoquan