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Top viewed research performed by San Antonio Bioscience Organizations

EVALUATION OF THE SAFETY, TOLERABILITY, EFFICACY AND ACTIVITY OF AMX0035, A FIXED COMBINATION OF PHENYLBUTYRATE (PB) AND TAUROURSODEOXYCHOLIC ACID (TUDCA), FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)
UT Health San Antonio
Jackson, Carlayne E
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CONNECT: Synthesis of Highly Potent C-9 Artemisinin Derivatives for the Low-Cost Treatment of Artemisinin Resistant Malaria

Since its discovery from the extracts of sweet wormwood (Artemisia annua) in 1979. the anti-malarial drug artemisinin (3) is now the key starting material in the synthesis of life-saving artemisinin-based combination therapies (ACT). Yet. beginning in 2009. mutations in the parasites PfKelch13 protein began conferring artemisinin resistance in the Greater Mekong Subregion (GMS) (Figure 1).Since then. artemisinin resistance has been spreading and some ACT treatment failure rates have reached 26% to 46% in 2015.

The University of Texas at San Antonio
Frantz, Douglas
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