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San Antonio Medical Foundation

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The hypothalamus is the brain hub that regulates energy homeostasis. The genetic and molecular basis of thisregulation in humans is not well understood as access to this tissue is a major barrier and available onlypostmortem. To overcome the barrier of limited tissue access, we are generating induced pluripotent stem cell(iPSC)-derived neuronal cultures that recapitulate many of the features of hypothalamic neurons from thearcuate nucleus, including by benchmarking this in vitro model to in vivo events that are pivotal in hypothalamicdevelopment.

UT Health San Antonio
Lehman, Donna M

Basic Research

The University of Texas at San Antonio
Lee, Hyoung-gon