Dysfunctional serotonergic neuromodulation in mood-regulating circuits underlies many psychiatric diseases, thusunderstanding regulation of serotonin (5-HT) transmission is of fundamental importance. The 5-HT transporter(SERT) clears 5-HT from extracellular fluid with high-affinity, and is considered a primary controller of the strengthand duration of 5-HT signaling. Our studies have revealed that organic cation transporter 3 (OCT3), a low-affinity,but high-capacity transporter of monoamines, plays a critical role in 5-HT clearance as well.
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The University of Texas at San Antonio
The University of Texas at San Antonio
Southwest Research Institute
Southwest Research Institute
The University of Texas at San Antonio
The University of Texas at San Antonio